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An Amazon cargo plane barreled off a runway at Miami International Airport on Sunday, killing at least five people and injuring five others as it struck vehicles and was engulfed in flames, authorities said.

The aircraft overran the runway around 2 p.m. after arriving from San Juan, Puerto Rico, and plowed across a road used by warehouse workers and other businesses that surround the airport. Five people were killed, three critically injured and two others hospitalized with less severe injuries, Miami-Dade County officials told a news conference.

It wasn’t immediately clear if the pilots survived or those killed were all in vehicles when the plane struck.

The crash, which sent thick black smoke billowing into the sky, trapped the pilot and copilot in the cockpit and some occupants in cars, said Miami-Dade Rescue Fire Chief Ray Jadallah. The agency said crews also had to extricate a person who was trapped under a vehicle.

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